Olumiant is a prescription medication that is a Janus kinase (JAK) inhibitor, and is used to treat adults with severe alopecia areata.

Discover a once-daily pill for adults with severe alopecia areata

You could regrow your hair. Olumiant showed significant hair regrowth in some adults, resulting in 80% scalp coverage at 36 weeks.^*

^*Up to 22% of people taking 2 mg once daily compared to up to 5% taking the inactive pill in clinical studies.

00:00

[The words "Actor portrayal" animate in the upper left corner of the screen]

00:01-00:04

[A woman with severe alopecia areata takes a shower. The back of her head is shown, and she is missing hair.]

VO: With severe alopecia areata,...

00:05-00:06

[The camera follows a small tuft of hair falling down her shoulder, onto the shower floor.]

VO: …you can lose your hair.

00:07-00:10

[Within the hair, we see her hair figure sitting in the water current.]

VO: Moments left behind. Time feels swept away by hair loss.

00:11-00:13 [A second woman with severe alopecia areata wakes up to see hair on her pillow.]

Super: Olumiant is a prescription medicine used to treat adults with severe alopecia areata.

VO: Now you can regrow your hair with Olumiant,...

00:14-00:18

[Her hair figure is sitting on the pillow and gets disrupted by the spouse's shifting movement.]

Super: Olumiant is a prescription medicine used to treat adults with severe alopecia areata.

VO: ...the first FDA-approved oral treatment for adults with severe alopecia areata.

00:19-00:22

[The first woman is showering; you see her post-treatment hair.]

Super: Some adults taking Olumiant achieved 80% scalp hair coverage at 36 weeks.*

*Up to 22% of people taking 2 mg once daily compared to up to 5% taking the inactive pill in clinical studies.

VO: Just one pill each day may significantly regrow your hair at 36 weeks.

00:23-00:25

[The same woman in the shower, close up of the drain without a tuft of hair.]

Super: Don't start Olumiant if you have an infection, it can lower your ability to fight them.

VO: Don’t start Olumiant if you have an infection,...

00:25-00:27

[The same woman, exits the shower.]

Super: Don't start Olumiant if you have an infection, it can lower your ability to fight them.

VO: …as it can lower your ability to fight them.

00:27-00:32

[The same woman closes the shower door, walks toward the sunny window, and looks outside.]

Super: Serious, sometimes fatal infections, blood clots, cancers such as lymphoma and skin cancer, serious allergic reactions, tears in the stomach or intestines, and changes in lab results have occurred.

VO: Serious, sometimes fatal infections, blood clots, cancers such as lymphoma and skin cancer,...

00:33-00:37

[The second woman wakes up with post-treatment hair. Her partner is asleep next to her.]

VO: …serious allergic reactions, tears in the stomach or intestines, and changes in lab results have occurred.

00:38-00:43

[The second woman wakes up with post-treatment hair. She looks over at her pillow, which doesn't have a tuft of hair. She turns toward the camera with a smile on her face.]

Super: People 50 years and older with at least one heart disease risk factor have a higher risk of death, heart attack, stroke, and blood clots.

VO: People 50 years and older with at least one heart disease risk factor have a higher risk of death, heart attack, stroke, and blood clots.

00:43-00:50

[The second woman and her spouse walk through the market, their arms intertwined.]

Super: Tell your doctor if you have had Tuberculosis (TB), hepatitis B or C, are prone to infections, or have been somewhere fungal infections are common.

VO: Tell your doctor if you have had Tuberculosis (TB), hepatitis B or C, are prone to infections, or have been somewhere fungal infections are common.

00:51-00:55

[The same woman holds up a bowl she finds and then cuts to her and her spouse talking to a vendor at the market]

Super: Before starting and while taking Olumiant, your doctor should check for TB and do blood tests.

VO: Before starting and while taking Olumiant, your doctor should check for TB and do blood tests.

00:55-00:58

[Olumiant logo, pill bottle, end card material appears on the screen]

Super: Olumiant end card. Learn more at olumiant.lilly.com 1-844-LillyRx (1-800-545-5979)

For pricing information, please visit lillypricinginfo.com/olumiant or call 1-800-LillyRx. Olumiant® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

VO: Ask your doctor about Olumiant.

00:58-1:00

[Lilly A MEDICINE COMPANY animates on a red background]

“It has worked so well for me. The once-a-day pill is easy to take."

John, actual Olumiant patient with severe alopecia areata

John was compensated for his time.

Discover Olumiant

Learn more about scalp hair regrowth and eyebrow & eyelash results

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Find Out How Olumiant Works

Select Safety Information

Olumiant may cause serious side effects, including:
Serious infections, including tuberculosis (TB), shingles, and others caused by bacteria, fungi, or viruses. Some people have died from these infections. Olumiant can make you more likely to get infections or make any infections you have worse. You should not start Olumiant if you have any kind of infection unless your doctor tells you it is okay. While taking Olumiant, tell your doctor right away if you have symptoms of an infection. If you get a serious infection, your doctor may stop Olumiant until your infection is controlled.

Increased risk of death in people 50 years of age or older who have at least 1 heart disease risk factor and take a medicine in a class of medicines called Janus kinase (JAK) inhibitors. Olumiant is a JAK inhibitor.

Cancer and immune system problems. Olumiant may increase your risk of lymphoma and other cancers. People taking a medicine in the class of medicines called JAK inhibitors have a higher risk of certain cancers, especially if you are a current or past smoker. Follow your doctor's advice about having your skin checked for skin cancer while taking Olumiant.

Increased risk of major cardiovascular events such as heart attack, stroke or death in people 50 years of age and older who have at least 1 heart disease risk factor and taking a medicine in the class of medicines called JAK inhibitors, especially if you are a current or past smoker. Get emergency help right away if you have any symptoms of a heart attack or stroke while taking Olumiant.

Blood clots in the veins of your legs or lungs, and arteries. This may be life-threatening and cause death. Blood clots in the veins of legs and lungs have happened more often in people who are 50 years of age or older and with at least 1 heart disease risk factor taking a medicine in the class of medicines called JAK inhibitors. Stop taking Olumiant and tell your doctor or get emergency help right away if you have any signs and symptoms of blood clots while taking Olumiant.

SAFETY SUMMARY WITH WARNINGS

WARNINGS - Olumiant may cause serious side effects, including:

Serious infections, including tuberculosis (TB), shingles, and others caused by bacteria, fungi, or viruses. Some people have died from these infections. Olumiant can make you more likely to get infections or make any infections that you have worse. Your doctor should test for TB before starting Olumiant and watch for TB symptoms during treatment. You should not start Olumiant if you have any kind of infection unless your doctor tells you it is okay. While taking Olumiant, tell your doctor right away if you have symptoms of an infection, such as:
- fever, sweating, or chills
- muscle aches
- cough
- shortness of breath
- blood in phlegm
- weight loss
- warm, red, or painful skin or sores on your body
- diarrhea or stomach pain
- burning with urination or urinating more often than normal
- feeling tired
If you get a serious infection, your doctor may stop Olumiant until your infection is controlled.
Increased risk of death in people 50 years of age or older who have at least 1 heart disease risk factor and are taking a medicine in a class of medicines called JAK inhibitors.
Cancer and immune system problems. Olumiant may increase your risk of lymphoma and other cancers, including skin cancers. People taking a medicine in the class of medicines called JAK inhibitors have a higher risk of certain cancers, including lymphoma and lung cancer, especially if you are a current or past smoker. Follow your doctor’s advice about having your skin checked for skin cancer while taking Olumiant.
Increased risk of major cardiovascular events such as heart attack, stroke or death in people 50 years of age and older who have at least 1 heart disease risk factor and taking a medicine in the class of medicines called JAK inhibitors, especially if you are a current or past smoker. Get emergency help right away if you have any symptoms of a heart attack or stroke while taking Olumiant, including:
- discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back
- severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw
- pain or discomfort in your arms, back, neck, jaw, or stomach
- shortness of breath with or without chest discomfort
- breaking out in a cold sweat
- nausea or vomiting
- feeling lightheaded
- weakness in one part or on one side of your body
- slurred speech
Blood clots in the veins of your legs or lungs, and arteries. This may be life-threatening and cause death. Blood clots in the veins of legs and lungs have happened more often in people who are 50 years of age or older and with at least 1 heart disease risk factor taking a medicine in the class of medicines called JAK inhibitors. Stop taking Olumiant and tell your doctor or get emergency help right away if you have any signs and symptoms of blood clots, including swelling, pain or tenderness in the leg, sudden chest pain, or shortness of breath, while taking Olumiant.
Allergic reactions. While taking Olumiant, if you have symptoms, such as rash (hives), trouble breathing, feeling faint or dizzy, or swelling of your lips, tongue, or throat, stop taking Olumiant and get emergency help right away. Some of these reactions seen in people taking Olumiant were serious.
Tears in the stomach or intestines. This happens most often in people who also take nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, or methotrexate. While taking Olumiant, tell your doctor right away if you have fever and stomach-area pain that does not go away, and a change in bowel habits.
Changes in laboratory test results. Your doctor should do blood tests before and while taking Olumiant. You should not take Olumiant if your white or red blood cell count is too low or your liver tests are too high. Your doctor may pause your treatment with Olumiant because of changes in these test results. Your doctor should also check your cholesterol levels approximately 12 weeks after you start Olumiant and as needed.

Common side effects

The most common side effects of Olumiant in people treated for alopecia areata include:

upper respiratory tract infections (cold or sinus infections)
headache
acne
increased cholesterol levels
increased muscle enzyme levels
urinary tract infection
increased liver enzyme levels
inflammation of hair follicles (folliculitis)

tiredness
lower respiratory tract infections
nausea
genital yeast infection
low red blood cell count (anemia)
low white blood cell count (neutropenia)
stomach-area (abdominal) pain
shingles (herpes zoster)
increased weight

The most common side effects of Olumiant in people treated for rheumatoid arthritis include:

upper respiratory tract infections (cold or sinus infections)
nausea

herpes simplex virus infections, including cold sores
shingles (herpes zoster)

These are not all the possible side effects of Olumiant. Tell your doctor if you have any side effects. You can report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch .

Before using

Before you use Olumiant, tell your doctor if you:

Are being treated for an infection, have an infection that won’t go away or keeps coming back, or think you have symptoms of an infection.
Have TB or have been in close contact with someone with TB.
Have had shingles (herpes zoster).
Have had hepatitis B or C, cancer, or blood clots in the veins of your legs or lungs.
Live, have lived, or have visited parts of the country that increase your risk of fungal infections. These may include the Ohio and Mississippi River valleys and the Southwest. Ask your doctor if you do not know if you have lived in an area where these infections are common.
Are a current or past smoker.
Have had a heart attack, other heart problems or stroke.
Have other medical conditions, including kidney or liver problems, low blood cell counts, diabetes, lung disease, HIV, or a weak immune system.
Have any stomach-area pain or have been diagnosed with inflammation in the large intestine (diverticulitis) or ulcers in your stomach or intestines.
Have recently received or plan to receive a vaccine. People taking Olumiant should not receive live vaccines.
Are pregnant or plan to become pregnant. It is not known if Olumiant may harm your unborn baby. If you become pregnant while taking Olumiant, call Eli Lilly and Company at 1-800-545-5979 to report the pregnancy.
Are breastfeeding or plan to breastfeed. You should not breastfeed while taking Olumiant and for 4 days after the last dose. Talk to your doctor about the best way to feed your baby while taking Olumiant.
Are taking other medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements. It is especially important to tell your doctor, if you take:
- a medicine called probenecid
- medicines that affect your immune system, such as biologic medications, other JAK inhibitors, or strong immunosuppressants (such as azathioprine or cyclosporine) since these may increase your risk of infection.
Are under age 18. It is not known if Olumiant is safe and effective in children.

How to take

Take Olumiant exactly as your doctor says.
Take Olumiant once a day by mouth with or without food.
Talk to your doctor if you cannot swallow tablets whole.
If you take too much Olumiant, call your doctor or poison control center at 1-800-222-1222, or go to the nearest hospital emergency room right away.

Learn more

Olumiant is a prescription medicine. For more information, call 1-800-545-5979.

This summary provides basic information about Olumiant but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Olumiant and how to take it. Your doctor is the best person to help you decide if Olumiant is right for you.

BA CON BS 14SEP2022

Please see full Prescribing Information, including Boxed Warning, and Medication Guide.

INDICATIONS

Olumiant^® (O-loo-me¯-ant) is a Janus kinase (JAK) inhibitor used to treat:

adults with severe alopecia areata.
adults with moderately to severely active rheumatoid arthritis after treatment with 1 or more medicines called tumor necrosis factor (TNF) blockers have been used, and did not work well enough or could not be tolerated.